Molecular and Cellular Basis for Beta Cell Therapy in Diabetes

IAP Research project P6/40

The network undertakes a research program (Belspo IAP-VI network P6/40) sponsored by Belgian Science Policy. The objective is to identify intervention targets through which survival and function of beta cells can be preserved or corrected. Our working hypothesis is that the phenotype of these cells determines their life span and their ability to respond to metabolic demands. Five basic laboratory projects address complementary ways to influence the beta cell phenotype in order to protect and maintain a functional beta cell mass long-term. Currently used drugs are examined for their influences on the functional state of these cells, and novel drug targets are searched for their ability to control beta cell survival and functions. Studies are undertaken to investigate how feeding maintains beta cell functions and how nutrient excess can impair their metabolic control and lead to diabetes. The role of cytokines and chemokines in beta cell dysfunction and death is further clarified. Clinical implementation of findings will be conducted in collaboration with the Belgian Diabetes Registry and the JDRF Center for Beta Cell Therapy in Diabetes.